FB2026_03 , released September 17, 2026
Allele: Dmel\RpiEP2456
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General Information
Symbol
Dmel\RpiEP2456
Species
D. melanogaster
Name
FlyBase ID
FBal0268310
Feature type
allele
Associated gene
Dmel\Rpi
Associated Insertion(s)
P{EP}RpiEP2456
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Wang et al., 2012)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EP}RpiEP2456
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{EP}
    Regulatory region(s)
    UAS
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutant flies show increased resistance to paraquat (10mM) and to hyperoxia (95% O[[2]]) compared to control flies. The mean lifespan shows a 39% increase compared to wild type.

        (Wang et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Expression of Rpi is reduced by 80% in the P{EP}RpiEP2456 insertion line, while expression of CG30409 remains unchanged relative to wild type.

        (Wang et al., 2012)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        RpiEP2456
        Name Synonyms
        Secondary FlyBase IDs
          References (1)