FB2026_02 , released June 18, 2026
Allele: Dmel\CaMKII1
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General Information
Symbol
Dmel\CaMKII1
Species
D. melanogaster
Name
FlyBase ID
FBal0268446
Feature type
allele
Associated gene
Dmel\CaMKII
Associated Insertion(s)
Carried in Construct
Also Known As
l(4)16
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(Hochman, 1997.7.29)
spontaneous
(Hochman, 1976, Hochman, 1974, Hochman, 1971)
Progenitor genotype
Cytology
Description

Lesion in CaMKII that results in a greatly reduced amount of CaMKII product, likely as a result of a shift to production of larger less stable isoforms.

(Johnson et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous animals have a normal heartbeat and injections of norepinephrine produce wild-type effects. However, the heart is unresponsive to serotonin in these animals.

      (Johnson et al., 2002)

      Lethality occurs during embryonic and larval development.

      (Hochman, 1976, Hochman, 1974)

      Lethal phase is during the embryonic to larval stages.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Isolated from: Knoxville, TN orchard population, 1963.

      (Hochman, 1997.7.29)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      CaMKII102EFb-1
      CaMKII1
      K-4
      (Hochman, 1997.7.29)
      l(4)102EFb1
      l(4)16
      (Dunn and Mercier, 2005, Johnson et al., 2002, Hochman, 1997.7.29)
      l(4)K-4
      Name Synonyms
      lethal(4)Knoxville-4
      Secondary FlyBase IDs
      • FBal0148117
      • FBal0011492
      References (6)