FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CCT3512
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General Information
Symbol
Dmel\CCT3512
Species
D. melanogaster
Name
FlyBase ID
FBal0268694
Feature type
allele
Associated gene
Dmel\CCT3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ghabrial et al., 2011)
Progenitor genotype
Cytology
Description

Amino acid replacement: G297D.

(Ghabrial et al., 2011)

Nucleotide substitution: G?A.

(Ghabrial et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:16,648,994..16,648,994 [+]
Nucleotide change:

G16648994A

Reported nucleotide change:

G?A

Amino acid change:

G297D | CCT3-PA; G297D | CCT3-PB; G297D | CCT3-PC; G297D | CCT3-PD

Reported amino acid change:

G297D

(Ghabrial et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CCT3512 heterozygotes show third instar larval neuromuscular junctions with fewer branches and fewer boutons, as compared to controls; CCT3512/Df(3R)vine2 transheterozygotes bearing a copy of CCT3+tGa do not show this defect.

      (Syed et al., 2019)

      Cctγ512 mutant third instar larvae exhibit tracheal terminal cells with multiple convoluted lumens and moderate pruning.

      (Ghabrial et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      CCT3512/CCT3[+], mtgoe02963 has partially lethal phenotype

      (Syed et al., 2019)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      mtgoe02963, CCT3512 double heterozygotes eclose at lower than expected mendelian ratio from cross between single heterozygotes.

      (Syed et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      512
      (Ghabrial et al., 2011)
      CCT3512
      (Syed et al., 2019)
      Cctγ512
      Name Synonyms
      Secondary FlyBase IDs
        References (2)