FlyBase Allele Report: Hsap\DTNBP1[UAS.cSa]

General Information

Symbol

Hsap\DTNBP1^UAS.cSa

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct a of Shao

FlyBase ID

FBal0268976

Feature type

allele

Associated gene

Hsap\DTNBP1

Associated Insertion(s)

Carried in Construct

P{UAS-DTNBP1.S}

Key Links

Transgenic product class

cDNA

(Shao et al., 2011)

wild_type

(Shao et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Shao et al., 2011)

wild_type

(Shao et al., 2011)

Mutagen

in vitro construct

(Shao et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-DTNBP1.S}

Cytology

Description

UAS regulatory sequences drive expression of full length Hsap\DTNBP1 cDNA.

(Shao et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\DTNBP1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/Hsap\DTNBP1^UAS.cSa is a suppressor of abnormal neurophysiology | larval stage phenotype of Dysb^e01028

(Shao et al., 2011)

Scer\GAL4^elav-C155/Hsap\DTNBP1^UAS.cSa is a suppressor of abnormal memory | adult stage phenotype of Dysb^e01028

(Shao et al., 2011)

Scer\GAL4^repo/Hsap\DTNBP1^UAS.cSa is a suppressor of abnormal locomotor behavior | adult stage phenotype of Dysb^e01028

(Shao et al., 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/Hsap\DTNBP1^UAS.cSa is a suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of Dysb^e01028

(Shao et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Pan-neuronal expression of Hsap\DTNBP1^Scer\UAS.cSa under the control of Scer\GAL4^elav-C155 rescues the larval neuromuscular junction excitatory junctional current defects and the adult short term memory defects observed in dysb^e01028 mutants.

Expression of Hsap\DTNBP1^Scer\UAS.cSa in the glia under the control of Scer\GAL4^repo partially suppresses the locomotor defects seen in dysb^e01028 mutants. The increase in dopamine levels seen in dysb^e01028 mutant heads is also suppressed.

(Shao et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\DTNBP1^Scer\UAS.cSa

Hsap\DTNBP1^UAS.cSa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Shao

Secondary FlyBase IDs

References (1)

Report Sections

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