FB2025_05 , released December 11, 2025
Allele: Dmel\N+t40
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General Information
Symbol
Dmel\N+t40
Species
D. melanogaster
Name
FlyBase ID
FBal0269855
Feature type
allele
Associated gene
Dmel\N
Associated Insertion(s)
Carried in Construct
P{N.gt-wt}
PBac{N.gt-wt}
Also Known As
Ngt-wt
Key Links
Transgenic product class
genomic_DNA
(Leonardi et al., 2011)
wild_type
(Leonardi et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Leonardi et al., 2011)
wild_type
(Leonardi et al., 2011)
Mutagen
in vitro construct
(Leonardi et al., 2011)
Progenitor genotype
Carried in construct
P{N.gt-wt}
PBac{N.gt-wt}
Cytology
Description

A 40 kb N genomic transgene in which the expression of N is driven by the endogenous promoter and enhancers.

(Leonardi et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
N
Encoded product / tool
N
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals lacking endogenous N (Df(1)N-54l9/Y) and rescued by one copy of N+t40 do not exhibit a loss of wing veins.

      (Lee et al., 2013)

      Flies that carry a single copy of N+t40 in a wild-type genetic background display extra veins in the wing. This phenotype is dosage sensitive as animals carrying two copies of N+t40 show an enhancement of the extra and expanded wing vein phenotypes with occasional blisters in the wing.

      (Leonardi et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      N+t40 is a suppressor | partially of visible | heat sensitive phenotype of Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU

      (Müller et al., 2013)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      N+t40 is a suppressor of wing margin | heat sensitive phenotype of Hsap\GXYLT1UAS.Tag:HA, Scer\GAL4nub-AC-62

      (Lee et al., 2013)

      N+t40 is a suppressor | partially of wing blade posterior compartment | heat sensitive phenotype of Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU

      (Müller et al., 2013)
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa is dominantly partially suppressed if the flies also carry N+t40.

      (Müller et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      N+t40 rescues N55e11

      (Pandey et al., 2018)

      N+t40 rescues N55e11

      (Leonardi et al., 2011)
      Comments

      The wings of flies that carry a single copy of N+t40 in a N55e11/+ genetic background appear normal compared to wild-type. The lethality of N55e11 in hemizygous males can be rescued with by a single copy of N+t40. The rescued flies resemble wild-type animals.

      (Leonardi et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      N+t40
      Notchgt-wt
      (Müller et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)