FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tsf2Y533F.ΔGPI.UAS
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General Information
Symbol
Dmel\Tsf2Y533F.ΔGPI.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0270286
Feature type
allele
Associated gene
Dmel\Tsf2
Associated Insertion(s)
Carried in Construct
P{UAS-Tsf2.Y533F.ΔGPI}
Key Links
Transgenic product class
inframe_deletion
(Tiklová et al., 2010)
missense_variant
(Tiklová et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Tiklová et al., 2010)
missense_variant
(Tiklová et al., 2010)
Mutagen
in vitro construct
(Tiklová et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Tsf2.Y533F.ΔGPI}
Cytology
Description

UAS drives expression of Tsf2 containing a Y533F substitution in the C-terminal lobe, which abolishes its iron binding capacity, and lacking amino acids 798-820 (the GPI modification site), thereby generating a secreted protein.

(Tiklová et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Tsf2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4en.PU/Tsf2Y533F.ΔGPI.UAS fails to rescue Tsf2ex234

      (Tiklová et al., 2010)
      Comments

      Scer\GAL4en.PU-mediated expression of Tsf2Y533F.ΔGPI.Scer\UAS fails to rescues septate junction assembly in Tsf2ex234 mutants.

      (Tiklová et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Tsf2Y533F.ΔGPI.Scer\UAS
      Tsf2Y533F.ΔGPI.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)