FB2026_02 , released June 18, 2026
Allele: Dmel\AhcyL2NIG.8956R
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General Information
Symbol
Dmel\AhcyL2NIG.8956R
Species
D. melanogaster
Name
FlyBase ID
FBal0276226
Feature type
allele
Associated gene
Dmel\AhcyL2
Associated Insertion(s)
Carried in Construct
P{NIG.8956R}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
in vitro construct
(Japanese National Institute of Genetics, 2012.5.21)
Progenitor genotype
Carried in construct
P{NIG.8956R}
Cytology
Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-8956R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of AhcyL2NIG.8956R driven by Scer\GAL4Act5C.Switch.PR (in males fed RU486 during adulthood, to avoid developmental effects) significantly extends lifespan compared to controls; at 40 days old, age-dependent decline in climbing ability (seen in controls) is significantly suppressed in RU486-fed males. Intestinal integrity (measured with the 'Smurf assay') is significantly better in 50 day old females with expression of AhcyL2NIG.8956R driven by Scer\GAL4Act5C.Switch.PR, compared to controls.

      (Parkhitko et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ahcy89ENIG.8956R
      AhcyL2NIG.8956R
      Name Synonyms
      Secondary FlyBase IDs
        References (2)