FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HnRNAi.Sym.UAS
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General Information
Symbol
Dmel\HnRNAi.Sym.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0277053
Feature type
allele
Associated gene
Dmel\Hn
Associated Insertion(s)
Carried in Construct
P{UAS-Hn.RNAi.Sym}
Key Links
Transgenic product class
RNAi_reagent
(Neckameyer et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Neckameyer et al., 2007)
Mutagen
in vitro construct
(Neckameyer et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Hn.RNAi.Sym}
Cytology
Description

UAS regulatory sequences positioned at either end of the coding region drive expression of a full-length Hn cDNA, in both sense and antisense orientation, resulting in the generation of dsRNA.

(Neckameyer et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Significant embryonic lethality is observed upon expression of HndsRNA.Sym.Scer\UAS under the control of Scer\GAL4da.G32. However, later development is unaffected as adult eclosion levels are unchanged.

      Knockdown of Hn in the larval fat body and haemocytes through expression of HndsRNA.Sym.Scer\UAS under the control of Scer\GAL4Cg.PA results in a significant increase in locomotion relative to controls, at both the first and second days of the third-instar larval stage. Mouth hook contractions are significantly increased in these larvae. No changes in white prepupal heart rate are found.

      (Neckameyer et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      HnRNAi.Sym.UAS
      HndsRNA.Sym.Scer\UAS
      HndsRNA.Sym.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)