FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Etf-QOG65E
Open Close
General Information
Symbol
Dmel\Etf-QOG65E
Species
D. melanogaster
Name
FlyBase ID
FBal0277141
Feature type
allele
Associated gene
Dmel\Etf-QO
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Alves et al., 2012)
Mutagen
ethyl methanesulfonate
(Alves et al., 2012)
Progenitor genotype
Cytology
Description

Amino acid replacement: G65E.

(Alves et al., 2012)

Lesion within the FAD binding domain.

(Alves et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:9,911,559..9,911,559 [+]
Nucleotide change:

G9911559A

Amino acid change:

G65E | Etf-QO-PA; G65E | Etf-QO-PB

Reported amino acid change:

G65E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Alves et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  multiple acyl-CoA dehydrogenase deficiency
      CEA
      (Alves et al., 2012)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Once fertilized, early embryonic development of embryos derived from Etf-QOG65E germline clones is normal, without obvious mitotic defects during syncitial blastoderm, and with normal blastoderm cellularization and germ-band extension. However, during the onset of germ-band retraction there are gross morphological defects and a significant induction of apoptosis.

      Large somatic follicular mutant clones and large mutant clones in the larval wing disc fail to show any defects. Likewise, egg chamber development is normal when the germline is mutant.

      (Alves et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Etf-QOG65E
      Name Synonyms
      Secondary FlyBase IDs
        References (1)