FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\BTBD9wlst2
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General Information
Symbol
Dmel\BTBD9wlst2
Species
D. melanogaster
Name
wanderlust 2
FlyBase ID
FBal0277784
Feature type
allele
Associated gene
Dmel\BTBD9
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Freeman et al., 2012)
Mutagen
P-element activity
(Freeman et al., 2012)
Progenitor genotype
P{SUPor-P}BTBD9KG07859
(Freeman et al., 2012)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a deletion that removes part of the BTBD9 gene.

(Freeman et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  restless legs syndrome
      CEA
      (Freeman et al., 2012)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The total duration of sleep per 24 hour period is not significantly different from wild type. However, during the night the mean sleep bout length is decreased, the mean sleep bout number is increased and the amount of wake after sleep onset is increased in the mutant flies, indicating fragmented night-time sleep. These defects can be rescued by feeding the flies 1mM Prampipexole for 3 days.

      Mutant flies are hyperlocomotive when enclosed within a restrictive space.

      (Freeman et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      BTBD9wlst2
      dBTBD9wlst2
      (Freeman et al., 2012)
      Name Synonyms
      wanderlust
      (Freeman et al., 2012)
      wanderlust 2
      Secondary FlyBase IDs
        References (1)