FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\FicH375A.UAS
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General Information
Symbol
Dmel\FicH375A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0277874
Feature type
allele
Associated gene
Dmel\Fic
Associated Insertion(s)
Carried in Construct
P{UAS-Fic.H375A}
Key Links
Transgenic product class
missense_variant
(Rahman et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Rahman et al., 2012)
Mutagen
in vitro construct
(Rahman et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-Fic.H375A}
Cytology
Description

UASt regulatory sequences drive expression of a mutant form of Fic in which the histidine at amino acid 375 has been replaced by alanine.

(Rahman et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Fic
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing FicH375A.Scer\UAS under the control of Scer\GAL4arm.PS are viable and do not display any externally visible phenotypes.

      (Rahman et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      FicH375A.UAS/Scer\GAL4arm.PS fails to rescue Fic55

      (Rahman et al., 2012)

      FicH375A.UAS/Scer\GAL4repo fails to rescue Fic55

      (Rahman et al., 2012)
      Comments

      Expression of FicH375A.Scer\UAS under the control of Scer\GAL4arm.PS fails to rescue the loss of the ON transients in Fic55 mutant electroretinograms.

      Expression of FicH375A.Scer\UAS under the control of Scer\GAL4repo fails to rescue the loss of the ON transients in Fic55 mutant electroretinograms. The defects in phototaxis seen in Fic55 mutants are also not rescued.

      (Rahman et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      FicH375A.Scer\UAS
      FicH375A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)