FB2026_02 , released June 18, 2026
Allele: Dmel\eIF2AMI06462
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General Information
Symbol
Dmel\eIF2AMI06462
Species
D. melanogaster
Name
FlyBase ID
FBal0278492
Feature type
allele
Associated gene
Dmel\eIF2A
Associated Insertion(s)
Mi{MIC}eIF2AMI06462
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - molecular evidence

    (Lowe and Montell, 2022)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{MIC}eIF2AMI06462
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{MIC}
    Also carries
    attP
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        eIF2Ac00723/eIF2AMI06462 transheterozygous males show small seminal vesicles. eIF2Ac00723/eIF2AMI06462 transheterozygotes show at least one bundle of coiled sperm at the testis base but lack mature sperm in the seminal vesicle.

        In eIF2Ac00723/eIF2AMI06462 transheterozygous males, the testes contain fewer cystic bulges, lack waste bags, and contain many disorganized spermatids that appeared to be in tangled "knots", in contrast to the highly ordered structure of controls.

        (Lowe and Montell, 2022)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        CG7414MI06462
        (Bellen, 2012.10.23)
        Mi
        (Lowe and Montell, 2022)
        eIF2AMI06462
        Name Synonyms
        Secondary FlyBase IDs
          References (2)