The expression of Spc105R^HMS01752 under the control of Scer\GAL4^ey-OK107 leads to pharate lethality, P11-P15; P15 pharates fail to make proper head structures, instead possessing a remnant structure attached to the thorax that closely resembles the labellum and esophagus, but no antennae, eyes, ocelli or other mouthparts; there is a near-completely developed brain inside the thorax, located ventrally to the dorsal longitudinal muscles and attached to the ventral nerve cord at an orthogonal angle; the central brain and optic lobe, as well as individual neuropils (medulla, lobula, lobula plate and central complex) can be identified but have defective morphology; optic lobes are deformed toward the posterior; the lamina, retina or ocelli structures are not readily identifiable.