FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\waplAG
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General Information
Symbol
Dmel\waplAG
Species
D. melanogaster
Name
FlyBase ID
FBal0279992
Feature type
allele
Associated gene
Dmel\wapl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

gain of function allele

Mutagen
    Nature of the Allele
    Allele class

    gain of function allele

    (Cunningham et al., 2012)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nonsense mutation at Q271 in the large wapl isoform. This results in truncation of the large isoform, without affecting the small isoform.

    (Cunningham et al., 2012)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:2,156,622..2,156,622 [-]
    Nucleotide change:

    C2156622T

    Reported nucleotide change:

    C?T

    Amino acid change:

    Q271term | wapl-PA; Q271term | wapl-PC

    Reported amino acid change:

    Q271term

    (Cunningham et al., 2012)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        waplAG/+ suppresses the pairing-sensitive silencing of mini-w that is seen in the the P{wen.8}10C insertion: P{wen.8}10C homozygotes carrying one copy of waplAG in a w[-] background have yellow eyes, while P{wen.8}10C homozygotes in a wapl[+] w[-] background have white eyes. waplAG has no effect on the eye colours of flies heterozygous for P{wen.8}10C in a w[-] background.

        Most homozygotes die during the pupal stage without the development of cuticle. Adult male escapers have sex comb teeth on all three legs.

        Embryos derived from homozygous female germline clones can be paternally rescued by a wild-type copy of wapl.

        Homozygous female germline clones show in an increase in non-disjunction of the X and 4th chromosomes compared to control clones.

        (Cunningham et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The addition of pds5e3/+ further darkens the eye colour of flies homozygous for P{wen.8}10C in a waplAG/+ w[-] background.

        The addition of Nipped-B29 lightens the eye colour of flies homozygous for P{wen.8}10C in a waplAG/+ w[-] background.

        (Cunningham et al., 2012)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        waplAG is partially rescued by Scer\GAL4arm.PS/waplUAS.S

        (Cunningham et al., 2012)
        Not rescued by

        waplAG is not rescued by waplUAS.L/Scer\GAL4arm.PS

        (Cunningham et al., 2012)
        Comments

        The lethality of waplAG is partially rescued by expression of waplScer\UAS.S under the control of Scer\GAL4arm.PS, but is not rescued by expression of waplScer\UAS.L under the control of Scer\GAL4arm.PS.

        (Cunningham et al., 2012)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        waplAG
        (Cunningham et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)