FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Saur\spa2.ZAβ3.UAS.Tag:MYC,Tag:SS(nec)
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General Information
Symbol
Saur\spa2.ZAβ3.UAS.Tag:MYC,Tag:SS(nec)
Species
S. aureus
Name
FlyBase ID
FBal0280257
Feature type
allele
Associated gene
Saur\spa
Associated Insertion(s)
Carried in Construct
P{UAS-ZAβ3.2}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Luheshi et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-ZAβ3.2}
Cytology
Description

UASt regulatory sequences drive expression of a head-to-tail dimer of a Hsap\APP-binding polypeptide derived from Saur\spa that is tagged with Tag:MYC and fused to an N-terminal Tag:SS(nec) secretion signal.

(Luheshi et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Saur\spa
Tagged with
Tag:MYC
Tag:SS(nec)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease
      modeled by Hsap\APPArctic.UAS.Tag:SS(nec)
      (Luheshi et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Flies co-expressing Saur\spa2.ZAβ3.Scer\UAS.T:Hsap\MYC,T:SS-nec with Hsap\APPArctic.Scer\UAS.T:SS-nec under the control of Scer\GAL4elav-C155 live almost as long as wild-type controls.

      Co-expression of Saur\spa2.ZAβ3.Scer\UAS.T:Hsap\MYC,T:SS-nec using Scer\GAL4elav-C155 restores the lifespan of flies expressing Hsap\APPScer\UAS.T:SS-nec alone to wild-type levels.

      Co-expression of Saur\spa2.ZAβ3.Scer\UAS.T:Hsap\MYC,T:SS-nec using Scer\GAL4GMR.PF restores the eye-morphology in flies expressing Hsap\APPArctic.Scer\UAS.T:SS-nec alone.

      (Luheshi et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Saur\spa2.ZAβ3.Scer\UAS.T:Hsap\MYC,T:SS-nec
      Saur\spa2.ZAβ3.UAS.Tag:MYC,Tag:SS(nec)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)