FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hsp27-0.7
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General Information
Symbol
Dmel\Hsp27-0.7
Species
D. melanogaster
Name
FlyBase ID
FBal0282041
Feature type
allele
Associated gene
Dmel\Hsp27
Associated Insertion(s)
P{EP}Hsp27-0.7
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Hao et al., 2007)
Mutagen
Delta2-3 transposase
(Hao et al., 2007)
Progenitor genotype
P{EP}Hsp27EP3583
(Hao et al., 2007)
Associated Insertion(s)
P{EP}Hsp27-0.7
Cytology
Description

Activation of the P{EP} element in Hsp27EP3583 has resulted in a 707bp deletion of the entire Hsp27 coding region (213aas), whilst retaining the starting element. Three additional nucleotides (GAA) are found at the junction of the deletion breakpoints.

(Hao et al., 2007)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:9,384,165..9,384,871 [+]
Comment:

707 bp deletion resulting from the imprecise excision of P{EP}Hsp27{EP3583]. Deletion boundaries are from published sequence. Three bases (GAA) are inserted at the site of the deletion.

(Hao et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous Hsp27-0.7 mutants do not exhibit any developmental problems. Egg production is comparable to wild type, and the ratio of progeny is normal. Response to heat and oxidative stress (paraquat treatment) is also comparable to controls. Reduced resistance to starvation is seen, with survivorship reduced by 39% compared to wild type and heterozygous controls. Moreover, male Hsp27-0.7 homozygotes show a 19.8% decrease in mean lifespan compared to wild type controls and a 26.2% reduction in comparison with heterozygotes. The increase in death rate begins at ~30 days. Maximum lifespan is unaffected.

      (Hao et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsp27-0.7
      hsp27-0.7
      (Sudi et al., 2008, Hao et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)