FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\α-CatRNAi.1.UAS
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General Information
Symbol
Dmel\α-CatRNAi.1.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0282554
Feature type
allele
Associated gene
Dmel\α-Cat
Associated Insertion(s)
Carried in Construct
P{UAS-α-Cat.RNAi.1}
Key Links
Transgenic product class
RNAi_reagent
(Seppa et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Seppa et al., 2008)
Mutagen
in vitro construct
(Seppa et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-α-Cat.RNAi.1}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat targeting a 451bp fragment beginning 540bp after the α-Cat start codon.

(Seppa et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
α-Cat
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of α-Cat1.dsRNA.Scer\UAS under the control of Scer\GAL4GMR.PF causes severe disruptions in patterning of inter-ommatidial precursor cells, manifesting as a rough eye phenotype in the adult fly. Inter-ommatidial precursor cell (IPC) patterning errors are observed at 41 hours after pupal formation. An increase in the number of IPCs is seen, and clustering of IPCs around the bristles. Three cells are commonly observed to share the 3[o] cell niche equally, where normally a single cell is found in this position.

      (Seppa et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      α-Cat1.dsRNA.Scer\UAS
      α-Cat1.dsRNA.UAS
      α-CatRNAi.1.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)