FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ScrHD.DD.UAS
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General Information
Symbol
Dmel\ScrHD.DD.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0282598
Feature type
allele
Associated gene
Dmel\Scr
Associated Insertion(s)
Carried in Construct
P{UAS-Scr.HD.DD}
Key Links
Transgenic product class
inframe_deletion
(Papadopoulos et al., 2010)
loss_of_function_variant
(Papadopoulos et al., 2010)
missense_variant
(Papadopoulos et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Papadopoulos et al., 2010)
loss_of_function_variant
(Papadopoulos et al., 2010)
missense_variant
(Papadopoulos et al., 2010)
Mutagen
in vitro construct
(Papadopoulos et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Scr.HD.DD}
Cytology
Description

UAS regulatory sequences drive expression of the Scr C terminus containing the YPWM motif and the homeodomain (HD). The homeodomain carries amino acid substitutions T6D and S7D (these mutations have been shown to result in an inactive variant in the full-length protein and they behave in a similar manner in the truncated peptide).

(Papadopoulos et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Scr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of the constitutively inactive ScrDD.Scer\UAS under the control of Scer\GAL4hs.PB fails to induce ectopic salivary glands in the embryonic head. The embryos expressing ScrDD.Scer\UAS display a normal pair of salivary glands, similar to that of controls.

      Ectopic expression of ScrDD.Scer\UAS under the control of Scer\GAL4Dll-md23 is unable to induce a reduction in the size of the arista as compared to the wild-type antenna.

      No abnormal eye phenotype is observed with Scer\GAL4dpp.blk1>ScrDD.Scer\UAS. The eyes of flies expressing ScrDD.Scer\UAS are indistinguishable from wild-type.

      (Papadopoulos et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ScrDD.Scer\UAS
      ScrHD.DD.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)