FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\MSRB3A.UAS
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General Information
Symbol
Hsap\MSRB3A.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0282646
Feature type
allele
Associated gene
Hsap\MSRB3
Associated Insertion(s)
Carried in Construct
P{UAS-hMsrB3.A}
Key Links
Transgenic product class
wild_type
(Lim et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Lim et al., 2012)
Mutagen
in vitro construct
(Lim et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-hMsrB3.A}
Cytology
Description

UASt regulatory sequences drive expression of the A isoform of Hsap\MSRB3.

(Lim et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\MSRB3
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult males and females expressing Hsap\MSRB3A.Scer\UAS under the control of either Scer\GAL4elav-C155 or Scer\GAL4da.G32 show increased resistance to oxidative stress (induced by paraquat) compared to controls.

      Adult males and females expressing Hsap\MSRB3A.Scer\UAS under the control of either Scer\GAL4elav-C155 or Scer\GAL4da.G32 show increased resistance to cold stress compared to controls.

      Adult males and females expressing Hsap\MSRB3A.Scer\UAS under the control of either Scer\GAL4elav-C155 or Scer\GAL4da.G32 show increased resistance to heat stress compared to controls.

      Adult males and females expressing Hsap\MSRB3A.Scer\UAS under the control of either Scer\GAL4elav-C155 or Scer\GAL4da.G32 at 29[o]C show an increased lifespan compared to controls.

      Expression of Hsap\MSRB3A.Scer\UAS under the control of Scer\GAL4elav-C155 delays the loss of climbing ability with age compared to controls.

      Females expressing Hsap\MSRB3A.Scer\UAS under the control of Scer\GAL4da.G32 show a significant increase in fecundity compared to age-matched controls at 5, 10, 15, 20 and 25 days after eclosion. Females expressing Hsap\MSRB3A.Scer\UAS under the control of Scer\GAL4elav-C155 show an increase in fecundity compared to age-matched controls at 5 and 10 days after eclosion.

      (Lim et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\MSRB3A.Scer\UAS
      Hsap\MSRB3A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)