FB2026_02 , released June 18, 2026
Allele: Dmel\TyrRS-mtOre
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General Information
Symbol
Dmel\TyrRS-mtOre
Species
D. melanogaster
Name
FlyBase ID
FBal0282671
Feature type
allele
Associated gene
Dmel\TyrRS-m
Associated Insertion(s)
Carried in Construct
PBac{TyrRS-m.Ore}
Key Links
Transgenic product class
polymorphic_sequence_variant
(Meiklejohn et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
polymorphic_sequence_variant
(Meiklejohn et al., 2013)
Mutagen
in vitro construct
(Meiklejohn et al., 2013)
Progenitor genotype
Carried in construct
PBac{TyrRS-m.Ore}
Cytology
Description

A 2326bp genomic fragment containing the entire coding region of Aats-tyr-m, isolated from the Oregon R strain.

(Meiklejohn et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
TyrRS-m
Encoded product / tool
TyrRS-m
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      The introduction of mtDNA from D. simulans, containing a mutation in a mitochondrial tRNA (Dsim\mt:tRNA:Yw501), into a D. melanogaster nuclear background, containing a transgenic mutation in the corresponding mitochondria-localized aminoacyl tRNA synthetase (Aats-tyr-mtOre, Df(2R)BSC606), is used to model mitochondrial disease resulting from incompatibility between the mitochondrial and nuclear genomes.

      (Holmbeck et al., 2015)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      When the 'simw[501]' mitochondrial genome, which contains the Dsim\mt:tRNA:Yw501 allele, is paired with the nuclear Aats-tyr-mtOre mutant allele (Aats-tyr-mtOre, Df(2R)BSC606), the following phenotypes are observed (compared to pairing with the wild type nuclear Aats-tyr-mtAutW132 allele (Aats-tyr-mtAutW132, Df(2R)BSC606)): scutellar bristle length is shorter; flight performance is poorer; climbing ability is stronger; indirect flight muscle mitochondria per unit area are increased, mitochondria display severely abnormal morphology and have large gaps in cristae structure.

      (Holmbeck et al., 2015)
      Complementation and Rescue Data
      Comments

      Aats-tyr-mtOre does not rescue the developmental delay seen in mitochondrial-nuclear hybrid strains containing the D. melanogaster nuclear genome and a D. simulans mitochondrial genome where the nuclear genome contains Aats-tyr-mOre/Df(2R)BSC606 and the mitochondrial genome contains Dsim\mt:tRNA:Yw501.

      (Meiklejohn et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Aats-tyr-mtOre
      TyrRS-mtOre
      Name Synonyms
      Secondary FlyBase IDs
        References (3)