FB2026_03 , released September 17, 2026
Allele: Dmel\TyrRS-mtAutW132
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General Information
Symbol
Dmel\TyrRS-mtAutW132
Species
D. melanogaster
Name
FlyBase ID
FBal0282672
Feature type
allele
Associated gene
Dmel\TyrRS-m
Associated Insertion(s)
Carried in Construct
PBac{TyrRS-m.AutW132}
Key Links
Transgenic product class
polymorphic_sequence_variant
(Meiklejohn et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
polymorphic_sequence_variant
(Meiklejohn et al., 2013)
Mutagen
in vitro construct
(Meiklejohn et al., 2013)
Progenitor genotype
Carried in construct
PBac{TyrRS-m.AutW132}
Cytology
Description

A 2326bp genomic fragment containing the entire coding region of Aats-tyr-m, isolated from the AutW132 strain.

(Meiklejohn et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
TyrRS-m
Encoded product / tool
TyrRS-m
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When developed at 25[o]C, Aats-tyr-mOre/Aats-tyr-mtAutW132 flies (containing mitochondrial-nuclear hybrid strains with both the D. melanogaster nuclear genome and a D. simulans mitochondrial genomes) are predominantly wild-type.

      (Hoekstra et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Flight performance is relatively strong while climbing ability is relatively weak in flies in which the 'simw[501]' mitochondrial genome, which contains the Dsim\mt:tRNA:Yw501 allele, is paired with the wild type nuclear Aats-tyr-mtAutW132 rescue allele (Aats-tyr-mtAutW132, Df(2R)BSC606). The morphology of indirect flight muscle mitochondria is only weakly affected.

      (Holmbeck et al., 2015)

      When developed at 25[o]C, Dsim\mt:tRNA:Yw501/Aats-tyr-mtAutW132 flies (containing mitochondrial-nuclear hybrid strains with both the D. melanogaster nuclear genome and a D. simulans mitochondrial genomes) are predominantly wild-type.

      (Hoekstra et al., 2013)
      Complementation and Rescue Data
      Comments

      Aats-tyr-mtAutW132 rescues the developmental delay seen in mitochondrial-nuclear hybrid strains containing the D. melanogaster nuclear genome and a D. simulans mitochondrial genome where the nuclear genome contains Aats-tyr-mOre/Df(2R)BSC606 and the mitochondrial genome contains Dsim\mt:tRNA:Yw501.

      (Meiklejohn et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Aats-tyr-mtAutW132
      TyrRS-mtAutW132
      Name Synonyms
      Secondary FlyBase IDs
        References (4)