FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Polr2AX161
Open Close
General Information
Symbol
Dmel\Polr2AX161
Species
D. melanogaster
Name
FlyBase ID
FBal0282695
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Single point mutation in the 3'UTR, approximately 40bp downstream of the stop codon.

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    T11563472A

    Reported nucleotide change:

    T?A

    Comment:

    T to A base change at position 40 of the Polr2A 3' UTR.

    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Embryos derived from homozygous female germline clones have a reduced cell number but otherwise develop apparently normally until at least gastrulation stage. Analysis of the early nuclear divisions indicates that 62% of embryos have 13 nuclear divisions followed by an extended interphase 13, 19% have only 12 nuclear divions, and 19% have partly 12 and partly 13 nuclear divisions with an extended interphase 13. The cell cycle pause in cycle 14 and cellularisation are initiated earlier than normal in the wild-type embryos.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Embryos derived from double mutant vfl294 RpII215X161 female germline clones undergo at least 13 divisions.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Polr2AX161
    RpII215X161
    Name Synonyms
    Secondary FlyBase IDs
      References (1)