FlyBase Allele Report: Dmel\Atpα[CJ7]

General Information

Symbol

Dmel\Atpα^CJ7

Species

D. melanogaster

Name

FlyBase ID

FBal0282772

Feature type

allele

Associated gene

Dmel\Atpα

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - molecular evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Ashmore et al., 2009)

Mutagen

ethyl methanesulfonate

(Ashmore et al., 2009)

Progenitor genotype

Cytology

Description

Mutations within the Atpα coding sequence were not detected - may affect non-coding sequences. Atpα protein expression levels are significantly reduced in heterozygotes.

(Ashmore et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of familial hemiplegic migraine

CEA

(Ashmore et al., 2009)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | dominant

(Ashmore et al., 2009)

abnormal neuroanatomy | dominant

(Ashmore et al., 2009)

bang sensitive (with Atpα^CJ4)

(Ashmore et al., 2009)

bang sensitive (with Atpα^CJ6)

(Ashmore et al., 2009)

bang sensitive (with Atpα^CJ13)

(Ashmore et al., 2009)

bang sensitive (with Atpα^DTS1R1)

(Ashmore et al., 2009)

bang sensitive (with Atpα^DTS2R3)

(Ashmore et al., 2009)

bang sensitive | dominant

(Ashmore et al., 2009)

bang sensitive | heat sensitive (with Atpα^CJ5)

(Ashmore et al., 2009)

bang sensitive | heat sensitive (with Atpα^CJ10)

(Ashmore et al., 2009)

bang sensitive | heat sensitive (with Atpα^CJ12)

(Ashmore et al., 2009)

lethal | heat sensitive (with Atpα^CJ6)

(Ashmore et al., 2009)

lethal | heat sensitive (with Atpα^CJ12)

(Ashmore et al., 2009)

lethal | heat sensitive (with Atpα^CJ13)

(Ashmore et al., 2009)

partially lethal - majority die (with Atpα^CJ4)

(Ashmore et al., 2009)

partially lethal - majority die | heat sensitive (with Atpα^CJ5)

(Ashmore et al., 2009)

partially lethal - majority die | heat sensitive (with Atpα^CJ10)

(Ashmore et al., 2009)

viable (with Atpα^CJ5)

(Ashmore et al., 2009)

viable (with Atpα^CJ6)

(Ashmore et al., 2009)

viable (with Atpα^CJ10)

(Ashmore et al., 2009)

viable (with Atpα^CJ12)

(Ashmore et al., 2009)

viable (with Atpα^CJ13)

(Ashmore et al., 2009)

Phenotype Manifest In

adult brain

(Ashmore et al., 2009)

Detailed Description

Statement

Reference

Heterozygotes are bang sensitive.

Atpα^CJ7/Atpα^CJ10 animals are viable at 25[o]C, but surviving adults at 29[o]C are bang-sensitive.

Atpα^CJ7/Atpα^CJ12 animals are viable at 25[o]C, but there are only rare escapers at 29[o]C - these rare escapers are bang-sensitive.

Atpα^CJ7/Atpα^CJ13 animals are viable and bang sensitive at 25[o]C, but all animals die at 29[o]C.

At 25[o]C, Atpα^CJ4/Atpα^CJ7 surviving adults are bang-sensitive. At 29[o]C, all trans-heterozygotes die.

Atpα^CJ5/Atpα^CJ7 animals are aphenotypic at 25[o]C, but surviving adults at 29[o]C are bang-sensitive.

Atpα^CJ6/Atpα^CJ7 animals are viable and bang-sensitive at 25[o]C, but all die at 29[o]C.

Heterozygotes display normal waking activity levels - i.e., normal circadian rhythms.

Heterozygotes display reduced waking locomotor activity in response to startle stimulation.

Aged heterozygous adult brains exhibit marked (small, non-clustering) vacuolar pathology throughout.

Aged heterozygous flight muscle does not exhibit myopathology.

Homozygous embryos form normal paracellular barriers and trachea.

Young heterozygous adults display no overt locomotor defects. However, these flies show significant, progressive bang sensitivity as they age.

(Ashmore et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: A recessive lethal unlinked to Atpα.

(Ashmore et al., 2009)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ATPalpha^CJ7

(Ashmore et al., 2009)

Atpα^CJ7

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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