FB2026_03 , released September 17, 2026
Allele: Hsap\AS3MTUAS.Tag:HA
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General Information
Symbol
Hsap\AS3MTUAS.Tag:HA
Species
H. sapiens
Name
FlyBase ID
FBal0282900
Feature type
allele
Associated gene
Hsap\AS3MT
Associated Insertion(s)
Carried in Construct
P{UAS-HA-hAS3MT}
Key Links
Transgenic product class
wild_type
(Muñiz Ortiz et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Muñiz Ortiz et al., 2011)
Mutagen
in vitro construct
(Muñiz Ortiz et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-HA-hAS3MT}
Cytology
Description

UAS regulatory sequence drive expression of N-terminally Tag:HA tagged Hsap\AS3MT coding sequence.

(Muñiz Ortiz et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\AS3MT
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\AS3MTScer\UAS.T:Ivir\HA1 in third-instar larvae exposed to 0.1mM inorganic arsenicals leads to the production of methylated arsenicals, with high levels of dimethylated arsenicals and somewhat lower levels of monomethylated arsenical species.

      Flies induced to express Hsap\AS3MTScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4da.G32 (through their foodlive for a significantly longer period (median lifetime) as compared with uninduced flies. The median lifetime is extended by 17%. No differences in developmental viability are found when this same genotype is exposed to a much lower concentration of inorganic arsenicals.

      (Muñiz Ortiz et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      A significantly enhanced rate of loss of heterozygosity in wtsx1 heterozygotes is only seen when both Hsap\AS3MTScer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4da.G32 and the flies are exposed to inorganic arsenicals.

      (Muñiz Ortiz et al., 2011)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\AS3MTScer\UAS.T:Ivir\HA1
      Hsap\AS3MTUAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)