FB2026_02 , released June 18, 2026
Allele: Hsap\SERPINI1P1-P1'.UAS
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General Information
Symbol
Hsap\SERPINI1P1-P1'.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0283102
Feature type
allele
Associated gene
Hsap\SERPINI1
Associated Insertion(s)
Carried in Construct
P{UAS-NS.P1-P1'}
Key Links
Transgenic product class
missense_variant
(Miranda et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Miranda et al., 2008)
Mutagen
in vitro construct
(Miranda et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-NS.P1-P1'}
Cytology
Description

UAS regulatory sequences drive expression of a mutant form of Hsap\SERPINI1 in which the P1 and P1' amino acids (located in the reactive centre loop and forming the pseudosubstrate for the target proteinase) have been changed from Met-Arg to Pro-Pro. The construct includes the human signal secretion peptide.

(Miranda et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\SERPINI1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The median lifespan of flies expressing Hsap\SERPINI1P1-P1'.Scer\UAS under the control of Scer\GAL4elav-C155 is similar to controls. Climbing ability is similar to controls.

      (Miranda et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\SERPINI1P1-P1'.Scer\UAS
      Hsap\SERPINI1P1-P1'.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)