FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HsfRNAi.UAS
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General Information
Symbol
Dmel\HsfRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0283110
Feature type
allele
Associated gene
Dmel\Hsf
Associated Insertion(s)
Carried in Construct
P{UAS-Hsf.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Fujikake et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Fujikake et al., 2008)
Mutagen
in vitro construct
(Fujikake et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-Hsf.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of inverted repeats corresponding to exons three to five of the Hsf cDNA, separated by the second intron of the Hsf gene.

(Fujikake et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsf
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing HsfdsRNA.Scer\UAS under the control of Scer\GAL4GMR.PF do not show any detectable eye phenotypes.

      (Fujikake et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of HsfdsRNA.Scer\UAS suppresses the ability of the HSF1-activating compound 17-AAG to rescue the degeneration seen in flies expressing a strong insertion of Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF. The amount of degeneration seen is similar to that observed in untreated flies. However, expression of HsfdsRNA.Scer\UAS also slightly enhances the compound eye degeneration in the absence of 17-AAG.

      (Fujikake et al., 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      HsfRNAi.UAS
      HsfdsRNA.Scer\UAS
      HsfdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)