FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fzIEAA.Act5C.EGFP
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General Information
Symbol
Dmel\fzIEAA.Act5C.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0283754
Feature type
allele
Associated gene
Dmel\fz
Associated Insertion(s)
Carried in Construct
P{Act5C(-FRT)fz-EGFP.IEAA}
Key Links
Transgenic product class
missense_variant
(Strutt et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Strutt et al., 2012)
Mutagen
FLPase
(Strutt et al., 2012)
Progenitor genotype
fzFRT.IEAA.Act5C.EGFP
(Strutt et al., 2012)
Carried in construct
P{Act5C(-FRT)fz-EGFP.IEAA}
Cytology
Description

The FRT cassette has been excised, allowing expression of the mutated fz coding sequence (containing the amino acid replacements I375A and E376A) under the control of the Act5C promoter. The fz protein sequence is tagged with EGFP.

(Strutt et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
Act5C
Encoded product / tool
fz
Tagged with
EGFP
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults carrying fzIEAA.Act5C.T:Avic\GFP-EGFP in a fz21 background have extra tarsal joints in the leg compared to wild type.

      (Strutt et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      fzIEAA.Act5C.T:Avic\GFP-EGFP shows poor rescue of the wing margin phenotype of fz21 fz2C1 double homozygous clones.

      (Strutt et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      fzIE>AA
      (Strutt et al., 2012)
      fzIEAA.Act5C.EGFP
      fzIEAA.Act5C.T:Avic\GFP-EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)