FB2026_02 , released June 18, 2026
Allele: Mmus\Msrb1UAS.SECIS
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General Information
Symbol
Mmus\Msrb1UAS.SECIS
Species
M. musculus
Name
FlyBase ID
FBal0283823
Feature type
allele
Associated gene
Mmus\Msrb1
Associated Insertion(s)
Carried in Construct
P{UAS-mMsrb1.SECIS}
Transgenic product class
wild_type
(Shchedrina et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Shchedrina et al., 2011)
Mutagen
in vitro construct
(Shchedrina et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-mMsrb1.SECIS}
Cytology
Description

UAS regulatory sequences drive expression of Mmus\Msrb1 coding sequences tagged at the 3' with the 3'UTR of Drosophila SelG, containing a SECID element (236bp after the stop codon).

(Shchedrina et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mmus\Msrb1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sixteen-day-old flies expressing Mmus\Msrb1Scer\UAS.SECIS in the nervous system, under the control of Scer\GAL4elav-C155 display increased survivability when fed medium with 5% sucrose and 5% hydrogen peroxide compared to controls. These flies also live longer on medium containing paraquat, compared to controls.

      Flies expressing Mmus\Msrb1Scer\UAS.SECIS in the nervous system (under the control of Scer\GAL4elav-C155) display increased resistance to starvation.

      Ubiquitous expression of Mmus\Msrb1Scer\UAS.SECIS under the control of Scer\GAL4da.G32 does not affect mean lifespan of virgin male and female flies. Expression specifically in the nervous system, under the control of Scer\GAL4elav-C155 equally does not affect mean lifespan.

      A 10 or 200nM sodium selenite supplement to the diet of flies expressing Mmus\Msrb1Scer\UAS.SECIS under the control of Scer\GAL4da.G32 does not affect the mean lifespan of either female or male flies.

      Ubiquitous expression of Mmus\Msrb1Scer\UAS.SECIS does not promote survival upon oxidative stress.

      Ubiquitous (Scer\GAL4da.G32) or nervous system (Scer\GAL4elav-C155) expression of Mmus\Msrb1Scer\UAS.SECIS does not affect reproductive vigour.

      (Shchedrina et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mmus\Msrb1Scer\UAS.SECIS
      Mmus\Msrb1UAS.SECIS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)