FB2026_02 , released June 18, 2026
Allele: Dmel\Fmr1UAS.Tag:MYC,Tag:HA
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General Information
Symbol
Dmel\Fmr1UAS.Tag:MYC,Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0284060
Feature type
allele
Associated gene
Dmel\Fmr1
Associated Insertion(s)
Carried in Construct
P{UAS-Fmr1.MYC.HA}
Key Links
Transgenic product class
wild_type
(Coffee et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Coffee et al., 2010)
Mutagen
in vitro construct
(Coffee et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Fmr1.MYC.HA}
Cytology
Description

Five copies of UAS drive expression of Fmr1 tagged with Tag:MYC and Tag:HA.

(Coffee et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Fmr1
Tagged with
Tag:HA
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Fmr1UAS.Tag:MYC,Tag:HA rescues Fmr1Δ50M

      (Coffee et al., 2010)
      Comments

      Expression of Fmr1Scer\UAS.T:Hsap\MYC,T:Ivir\HA1 under the control of Scer\GAL4elav-C155 completely rescued the synaptic overgrowth characterising the Fmr1Δ50M mutant, and the terminals become clearly more restricted in extent and refined in the number of synaptic boutons.

      Expression of Fmr1Scer\UAS.T:Hsap\MYC,T:Ivir\HA1 under the control of Scer\GAL4elav-C155 fully rescues both the enlarged neuromuscular junctional area and increased synaptic branching that characterise Fmr1Δ50M mutants.

      Pre-synaptic expression of Fmr1Scer\UAS.T:Hsap\MYC,T:Ivir\HA1 using Scer\GAL4elav-C155 completely rescues bouton number back to control levels in Fmr1Δ50M mutants.

      Scer\GAL4elav-C155>Fmr1Scer\UAS.T:Hsap\MYC,T:Ivir\HA1 can strongly rescue the mini-bouton number in Fmr1Δ50M mutants back to wild-type levels.

      Expression of Fmr1Scer\UAS.T:Hsap\MYC,T:Ivir\HA1 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 completely rescues the male fecundity defect that characterises Fmr1Δ50M mutants.

      Expression of Fmr1Scer\UAS.T:Hsap\MYC,T:Ivir\HA1 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 can strongly rescue the spermatid axoneme defects that characterise Fmr1Δ50M mutants.

      (Coffee et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fmr1Scer\UAS.T:Hsap\MYC,T:Ivir\HA1
      Fmr1UAS.Tag:MYC,Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)