FlyBase Allele Report: Dmel\EcR[RNAi.UAS]

General Information

Symbol

Dmel\EcR^RNAi.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0284079

Feature type

allele

Associated gene

Dmel\EcR

Associated Insertion(s)

Carried in Construct

P{UAS-EcR.RNAi}

Also Known As

EcR miRNA

Key Links

Transgenic product class

RNAi_reagent

(Lin et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Lin et al., 2009)

Mutagen

in vitro construct

(Lin et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-EcR.RNAi}

Cytology

Description

UAS drives expression of a transcript encoding two copies of mir-6-1 modified to target EcR.

(Lin et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

EcR

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^ey-OK107

(Lin et al., 2009)

abnormal size, with Scer\GAL4^ey-OK107

(Lin et al., 2009)

Phenotype Manifest In

adult mushroom body, with Scer\GAL4^ey-OK107

(Lin et al., 2009)

adult mushroom body gamma-lobe | adult stage, with Scer\GAL4^ey-OK107

(Lin et al., 2009)

eye, with Scer\GAL4^ey-OK107

(Lin et al., 2009)

Detailed Description

Statement

Reference

Expression of EcR^{miRNA.Scer\UAS} under the control of Scer\GAL4^{CG13917-BG01278} has no significant effect on male fertility (number of progeny produced by wild-type females mated to the knock-down males).

(Misra et al., 2017)

Expression using Scer\GAL4^ey-OK107 results in a small eye and 100% of mushroom bodies have a pruning defect.

(Lin et al., 2009)

Scer\GAL4^ey-OK107-mediated expression of EcR^{miRNA.Scer\UAS} blocks pruning of mushroom body gamma neurons, which maintain larval-type projections in the adult brain.

(Lin et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

EcR^RNAi.UAS

EcR^{miRNA.Scer\UAS}

EcR^miRNA.UAS

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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