FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Mmus\PrnpPG14.UAS
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General Information
Symbol
Mmus\PrnpPG14.UAS
Species
M. musculus
Name
FlyBase ID
FBal0284333
Feature type
allele
Associated gene
Mmus\Prnp
Associated Insertion(s)
Carried in Construct
P{UAS-Prp.PG14}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Deleault et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-Prp.PG14}
Cytology
Description

UASt drives expression of a 978bp fragment containing the pathogenic octarepeat PG14 variant of Mmus\Prnp.

(Deleault et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mmus\Prnp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Deleault et al., 2003)

      Mouse gene.

      PRNP:p.Gln59_Pro60ins[9ProHisGlyGlyGlyTrpGlyGln]
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      PRNP:p.Gln59_Pro60ins[ProHisGlyGlyGlyTrpGlyGln](9)
      PRNP, OCTAPEPTIDE REPEAT EXPANSION
      Associated human disease model(s)
      External database links
      ClinVar: PRNP_13394
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4GMR.PF-mediated expression of Mmus\PrnpPG14.Scer\UAS results in the normal arrangement of seven photoreceptor cells being preserved in >95% of ommatidia, from birth to 6 weeks of age - there is no significant retinal pathology.

      Flies homozygous for both Scer\GAL4elav-C155 and Mmus\PrnpPG14.Scer\UAS show a steep decline in climbing ability with advancing age from week 1 to week 3.

      30 day old flies homozygous for both Scer\GAL4elav-C155 and Mmus\PrnpPG14.Scer\UAS show appropriate development of the major brain centers, and no obvious loss of neuropil integrity or cell cortical number is observed.

      (Deleault et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mmus\PrnpPG14.Scer\UAS
      Mmus\PrnpPG14.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)