FB2026_03 , released September 17, 2026
Allele: Dmel\Doaz8
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General Information
Symbol
Dmel\Doaz8
Species
D. melanogaster
Name
FlyBase ID
FBal0284939
Feature type
allele
Associated gene
Dmel\Doa
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Zhao et al., 2013)
Progenitor genotype
Cytology
Description

G to A mutation of the 62nd nucleotide of exon 17, resulting in an amino acid change from Cys to Tyr in the predicted kinase catalytic domain.

(Zhao et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:28,920,751..28,920,751 [+]
Nucleotide change:

G28920751A

Reported nucleotide change:

G?A

Amino acid change:

C363Y | Doa-PAB; C344Y | Doa-PJ; C590Y | Doa-PK; C747Y | Doa-PL; C344Y | Doa-PM; C344Y | Doa-PN; C1803Y | Doa-PP; C987Y | Doa-PR; C275Y | Doa-PS; C344Y | Doa-PT; C344Y | Doa-PU; C275Y | Doa-PV; C647Y | Doa-PX; C1293Y | Doa-PY; C733Y | Doa-PZ

Reported amino acid change:

C?Y

Comment:

Site of amino acid change deduced from protein sequence data in paper.

(Zhao et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous germline clones result in early germ cell over-proliferation in testes. The overproliferating cells have branched fusomes, indicating that they are spermatogonia.

      (Zhao et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Doaz8
      (Zhao et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)