FB2026_03 , released September 17, 2026
Allele: Dmel\lushF121A.tGa
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General Information
Symbol
Dmel\lushF121A.tGa
Species
D. melanogaster
Name
FlyBase ID
FBal0284973
Feature type
allele
Associated gene
Dmel\lush
Associated Insertion(s)
Carried in Construct
P{lush.F121A.G}
Key Links
Transgenic product class
missense_variant
(Gomez-Diaz et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Gomez-Diaz et al., 2013)
Mutagen
in vitro construct
(Gomez-Diaz et al., 2013)
Progenitor genotype
lush+tGa
(Gomez-Diaz et al., 2013)
Carried in construct
P{lush.F121A.G}
Cytology
Description

3228bp genomic fragment spanning the entire lush transcription unit, extending from 958bp upstream of the start codon to 1693bp downstream of the stop codon. The coding sequence has been mutated to carry a F121A amino acid replacement.

(Gomez-Diaz et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
lush
Encoded product / tool
lush
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      lush+tGa, lushF121A.tGa, lushD118A.tGa and lushF121W.tGa each restore the sensitivity of Or67d-expressing neurons to cis-vaccenyl acetate (cVA) in lush1 mutants. The neuronal response across a 10,0000-fold range of cVA concentrations is similar in all four cases, with the only statistically significant difference being observed at the highest cVA concentration (100%), where flies rescued with lushF121W.tGa or with lushD118A.tGa show a slightly lower cVA sensitivity than those rescued with lush+tGa.

      lush+tGa, lushF121A.tGa, lushF121W.tGa and lushD118A.tGa each restore the spontaneous firing of Or67d-expressing neurons in lush1 mutants. There is no statistically significant difference in firing activity across the four genotypes.

      (Gomez-Diaz et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      LUSHF121A
      (Gomez-Diaz et al., 2013)
      lushF121A.tGa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)