Imprecise excision of the progenitor insertion, resulting in a 1311bp deletion which removes the first 2 exons of DLP (this includes the translation start site).
Mutants are more resistant to treatment with hydrogen peroxide than controls.
Mutant larvae show lower levels of apoptosis in the brain under oxidative stress than wild-type controls.
Daxx1 is a suppressor of abnormal oxidative stress response | adult stage phenotype of dj-1βex54
Daxx1 is a suppressor of abnormal oxidative stress response | larval stage phenotype of dj-1βex54
Daxx1 is a suppressor of radiation sensitive phenotype of dj-1βex54
Daxx1 is a suppressor of abnormal locomotor behavior | adult stage phenotype of dj-1βex54
The reduced survival and reduction in number of dopaminergic neurons in the brain seen in dj-1βex54 adults under oxidative stress conditions are suppressed if the animals are also mutant for DLP1.
The increased apoptosis seen in the brains of dj-1βex54 larvae under oxidative stress conditions is suppressed if the animals are also mutant for DLP1.
The sensitivity to UV irradiation seen in dj-1βex54 animals is suppressed if they are also mutant for DLP1.
The reduced climbing ability of dj-1βex54 flies is suppressed by DLP1.
