FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Daxx2
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General Information
Symbol
Dmel\Daxx2
Species
D. melanogaster
Name
FlyBase ID
FBal0285004
Feature type
allele
Associated gene
Dmel\Daxx
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Hwang et al., 2013)
Progenitor genotype
P{EPgy2}DaxxEY09290
(Hwang et al., 2013)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 1076bp deletion which removes the first 2 exons of DLP (this includes the translation start site).

(Hwang et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants are more resistant to treatment with hydrogen peroxide than controls.

      (Hwang et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Daxx2 is a suppressor of abnormal oxidative stress response | adult stage phenotype of dj-1βex54

      (Hwang et al., 2013)

      Daxx2 is a suppressor of radiation sensitive phenotype of dj-1βex54

      (Hwang et al., 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The reduced survival seen in dj-1βex54 adults under oxidative stress conditions are suppressed if the animals are also mutant for DLP2.

      The sensitivity to UV irradiation seen in dj-1βex54 animals is suppressed if they are also mutant for DLP2.

      (Hwang et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DLP2
      (Hwang et al., 2013)
      Daxx2
      Name Synonyms
      Secondary FlyBase IDs
        References (1)