FlyBase Allele Report: Dmel\nompC[a1]

General Information

Symbol

Dmel\nompC^a1

Species

D. melanogaster

Name

FlyBase ID

FBal0285133

Feature type

allele

Associated gene

Dmel\nompC

Associated Insertion(s)

Carried in Construct

Also Known As

jf24^a1, l(2)25Dc¹

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Szidonya and Reuter, 1988)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal auditory perception | recessive

(Eberl et al., 2000)

abnormal behavior | recessive

(Eberl et al., 2000)

abnormal locomotor behavior | recessive

(Eberl et al., 2000)

abnormal neurophysiology | recessive

(Eberl et al., 2000)

lethal - all die during embryonic stage | recessive

(George and Terracol, 1997)

uncoordinated | recessive

(Eberl et al., 2000)

Phenotype Manifest In

adult antennal nerve

(Eberl et al., 2000)

leg

(Eberl et al., 2000)

macrochaeta

(Eberl et al., 2000)

wing

(Eberl et al., 2000)

Detailed Description

Statement

Reference

Flies are uncoordinated showing frequent leg crossing and wings held up or out. Walking and righting ability is impaired. Spontaneous or induced (by light or mechanical stimuli) activity is vigorous. Mechanoreceptor potentials are reduced or absent in thoracic macrochaete bristles. The sound evoked response (measured via the antennal nerve) is somewhat reduced. ERGs are normal.

(Eberl et al., 2000)

Embryos do not exhibit any cuticular abnormalities.

(George and Terracol, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Due to a naming clash that goes back many years, two different alleles of nompC, with contrasting molecular lesions, were named nompC[1]. Thanks to user input, we have been able to disambiguate these two alleles. They are now called nompC[1] and nompC[a1]. The nompC[1] allele was generated in the Zuker lab by EMS (FBrf0127378). The nompC[a1] allele was made by Szidonya and Reuter (FBrf0047784) and published in 1988 as jf24[a1]. Allele jf24[a1] was renamed in Lindsley and Zimm 1992 (p. 353) as l(2)25Dc[1]. Allele l(2)25Dc[1] subsequently became nompC[1] based on a foot note in Kernan et al., 1994 (FBrf0073546) identifying l(2)25Dc as nompC. The references and data for jf24[a1]/l(2)25Dc[1]/nompC[1] have now been split from the nompC[1] FlyBase record and are associated with allele nompC[a1].

(FlyBase, 2009-)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

(Eberl et al., 1997)

jf24^a1

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Dc¹

(Eberl et al., 2000, George and Terracol, 1997)

nompC^a1

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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