FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ablftz.PH
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General Information
Symbol
Dmel\Ablftz.PH
Species
D. melanogaster
Name
FlyBase ID
FBal0285358
Feature type
allele
Associated gene
Dmel\Abl
Associated Insertion(s)
Carried in Construct
P{ftz-Abl.H}
Key Links
Transgenic product class
cDNA
(Hsouna et al., 2003)
wild_type
(Hsouna et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Hsouna et al., 2003)
wild_type
(Hsouna et al., 2003)
Mutagen
in vitro construct
(Hsouna et al., 2003)
Progenitor genotype
Carried in construct
P{ftz-Abl.H}
Cytology
Description

The neurogenic enhancer element of ftz drives expression of a wild-type Abl cDNA.

(Hsouna et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
ftz
Encoded product / tool
Abl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Co-expression of Ablftz.PH and AblKN.Scer\UAS suppresses all abnormal axonal crossovers.

      Co-expression of two copies of each AblKN.ftz and Ablftz.PH in Abl4 homozygous mutants results in axonal midline crossovers in 54% of embryos, a value almost identical to that observed in Abl4 mutants alone.

      (Hsouna et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Ablftz.PH partially rescues Abl2

      (Hsouna et al., 2003)

      Ablftz.PH partially rescues Abl4

      (Hsouna et al., 2003)
      Comments

      When two copies of Ablftz.PH are introduced into Abl4 mutants, axonal crossovers are reduced from 53% in Abl4 single mutants to 39% in the presence of the transgene.

      When two copies of Ablftz.PH are introduced into Abl2 mutants, axonal crossovers are reduced from 68% in Abl2 single mutants to 37% in the presence of the transgene.

      Co-expression of two copies of each AblKN.ftz and Ablftz.PH in Abl4 homozygous mutants results in axonal midline crossovers in 54% of embryos, a value almost identical to that observed in Abl4 mutants alone.

      (Hsouna et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ablftz.PH
      Name Synonyms
      Secondary FlyBase IDs
        References (1)