FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\5-HT1BΔIII-V
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General Information
Symbol
Dmel\5-HT1BΔIII-V
Species
D. melanogaster
Name
FlyBase ID
FBal0285935
Feature type
allele
Associated gene
Dmel\5-HT1B
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Gasque et al., 2013)
Mutagen
minos activity
(Gasque et al., 2013)
Progenitor genotype
Mi{ET1}5-HT1BMB05181
(Gasque et al., 2013)
Cytology
Description

Imprecise excision of Mi{ET1}5-HT1BMB05181 removing a 1344bp fragment from genomic DNA; exons encoding transmembrane segments III-V are deleted.

(Gasque et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:19,025,711..19,027,062 [-]
Comment:

1344 bp deletion in 5-HT1B resulting from the imprecise excision of Mi{ET1}5-HT1BMB05181. The endpoints were determined from the reported boundary genomic sequences.

(Gasque et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Similar to wild type, 5-HT1BΔIII-V larvae are sensitive to 100μM metitepine and show decreased feeding rates when fed with this drug.

      (Gasque et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      5-HT1BIII-V
      (Banu et al., 2022)
      5-HT1BΔIII-V
      (Liu et al., 2025, Gowda et al., 2023, Gasque et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)