FB2026_03 , released September 17, 2026
Allele: Dmel\barflyF48
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General Information
Symbol
Dmel\barflyF48
Species
D. melanogaster
Name
FlyBase ID
FBal0286396
Feature type
allele
Associated gene
barfly
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Singh and Heberlein, 2000)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      barflyF48 flies exhibit a higher than wild-type resistance to ethanol intoxication. The concentration of ethanol needed to induce loss of postural control in barflyF48 flies is significantly higher than in control flies.

      barflyF48 flies increase their locomotor activity upon exposure to ethanol. The degree of activation is not significantly different that found in wild-type controls, although sedation due to ethanol is delayed compared to controls. barflyF48 mutants take 30 minutes to be completely sedated after exposure to ethanol, compared to 20 minutes in controls. However, barflyF48 mutants take longer to recover from sedation than wild-type controls.

      Exposure to ethanol induces a significant increase in the maximal turning frequency in barflyF48 mutants compared to wild-type controls. However, the time needed for turning to stop completely is lengthened in barflyF48 flies. The level of turning in the absence of ethanol is very low and indistinguishable from wild-type. barflyF48 flies exhibit a significant increase in ethanol-induced locomotion between 2 and 7 minutes of ethanol exposure. This phenotype is not observed in controls.

      (Singh and Heberlein, 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      F48
      (Singh and Heberlein, 2000)
      barflyF48
      Name Synonyms
      Secondary FlyBase IDs
        References (1)