FlyBase Allele Report: Dmel\Epac[Δ1]

General Information

Symbol

Dmel\Epac^Δ1

Species

D. melanogaster

Name

FlyBase ID

FBal0287552

Feature type

allele

Associated gene

Dmel\Epac

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

FLPase

Nature of the Allele

Allele class

Mutagen

FLPase

(Efetova et al., 2013)

Progenitor genotype

PBac{WH}Epac^f07038

(Efetova et al., 2013)

P{XP}d04690

(Efetova et al., 2013)

Caused by aberration

Df(2R)Epac^Δ1

Cytology

Description

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in a 52252bp deletion that removes part of Epac.

(Efetova et al., 2013)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:6,740,809..6,793,196 [-]

Comment:

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in a 52252bp deletion that removes part of Epac.

(Efetova et al., 2013)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | larval stage (with Epac^Δ3)

(Kim et al., 2024)

fertile (with Epac^Δ3)

(Efetova et al., 2013)

viable (with Epac^Δ3)

(Efetova et al., 2013)

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage (with Epac^Δ3)

(Kim et al., 2024)

Detailed Description

Statement

Reference

Epac^Δ1/Epac^Δ3 animals have basal fluid secretion rates from the Malpighian tubules that are indistinguishable from wild type. however, the mutant Malpighian tubules fail to respond to the application of 2mM 8-pCPT-2'-O-Me-cAMP, an Epac-specific agonist.

The stimulatory effects of Dh44 peptide on fluid secretion rates from the Malpighian tubules is reduced compared to wild type in Epac^Δ1/Epac^Δ3 animals.

(Efetova et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Adcy1^rut-1, Epac^Δ1 has abnormal neurophysiology | larval stage phenotype

(Kim et al., 2024)

Phenotype Manifest In