FlyBase Allele Report: Dmel\Aplip1[ex]

General Information

Symbol

Dmel\Aplip1^ex

Species

D. melanogaster

Name

FlyBase ID

FBal0287828

Feature type

allele

Associated gene

Dmel\Aplip1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Klinedinst et al., 2013)

Mutagen

P-element activity

(Klinedinst et al., 2013)

Progenitor genotype

P{wHy}Aplip1^DG20707

(Klinedinst et al., 2013)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion that removes the entire Aplip1 locus (leaving the neighbouring LysX and mwh genes intact).

(Klinedinst et al., 2013)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage (with Df(3L)Fpa2)

(Klinedinst et al., 2013)

abnormal neuroanatomy | second instar larval stage

(Klinedinst et al., 2013)

abnormal neuroanatomy | third instar larval stage

(Klinedinst et al., 2013)

viable

(Klinedinst et al., 2013)

viable (with Df(3L)Fpa2)

(Klinedinst et al., 2013)

Phenotype Manifest In

NMJ bouton | larval stage (with Df(3L)Fpa2)

(Klinedinst et al., 2013)

NMJ bouton | second instar larval stage

(Klinedinst et al., 2013)

NMJ bouton | third instar larval stage

(Klinedinst et al., 2013)

Detailed Description

Statement

Reference

Aplip1^ex/Df(3L)Fpa2 larvae show defects in axonal transport, resulting in accumulations of protein in nerves.

Homozygous and Aplip1^ex/Df(3L)Fpa2 larvae show an increase in maximum bouton diameter at the neuromuscular junction. This defect is seen in both second and third instar mutant larvae. Splaying of the microtubules is seen in the enlarged boutons in homozygous third instar larvae.

(Klinedinst et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Aplip1^ex has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^BG380/futsch^EP1419

(Klinedinst et al., 2013)

Aplip1^ex has abnormal neuroanatomy | larval stage phenotype, suppressible by hiw^ΔN

(Klinedinst et al., 2013)

Aplip1^ex has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^BG380/wnd^UAS.cCa

(Klinedinst et al., 2013)

Suppressor of

Statement

Reference

Aplip1^ex is a suppressor of abnormal neuroanatomy | larval stage phenotype of hiw^ΔN

(Klinedinst et al., 2013)

Phenotype Manifest In

Suppressed by

Statement

Reference

Aplip1^ex has NMJ bouton | larval stage phenotype, suppressible by Scer\GAL4^BG380/futsch^EP1419

(Klinedinst et al., 2013)

Aplip1^ex has NMJ bouton | larval stage phenotype, suppressible by hiw^ΔN

(Klinedinst et al., 2013)

Aplip1^ex has NMJ bouton | larval stage phenotype, suppressible by Scer\GAL4^BG380/wnd^UAS.cCa

(Klinedinst et al., 2013)

Suppressor of

Statement

Reference

Aplip1^ex is a suppressor of NMJ bouton | larval stage phenotype of hiw^ΔN

(Klinedinst et al., 2013)

Aplip1^ex is a suppressor of neuromuscular junction | larval stage phenotype of hiw^ΔN

(Klinedinst et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of futsch^EP1419 under the control of Scer\GAL4^BG380 completely suppresses the increase in maximum bouton diameter which is seen at the neuromuscular junction in Aplip1^ex larvae.

Expression of futsch^EP1419 under the control of Scer\GAL4^BG380 fails to suppress the defects in axonal transport seen in Aplip1^ex larvae.

Aplip1^ex suppresses the increase in branch and bouton number at the neuromuscular junction which is seen in hiw^ΔNterm larvae. hiw^ΔNterm suppresses the increase in maximum bouton diameter which is seen at the neuromuscular junction in Aplip1^ex larvae.

Expression of wnd^Scer\UAS.cCa under the control of Scer\GAL4^BG380 suppresses the increase in maximum bouton diameter which is seen at the neuromuscular junction in Aplip1^ex larvae.

(Klinedinst et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Aplip1^ex is rescued by Scer\GAL4^BG380/Aplip1^UAS.cKa

(Klinedinst et al., 2013)

Comments

Expression of Aplip1^Scer\UAS.cKa under the control of Scer\GAL4^BG380 rescues the increase in maximum bouton diameter which is seen at the neuromuscular junction in Aplip1^ex larvae.

(Klinedinst et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Aplip1^ex

aplip1^ex213

(Siebert et al., 2015)

jip1^ex

(Klinedinst et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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