FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\PRKNG328E.UAS
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General Information
Symbol
Hsap\PRKNG328E.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0287976
Feature type
allele
Associated gene
Hsap\PRKN
Associated Insertion(s)
Carried in Construct
P{UAS-hParkin.G328E}
Key Links
Transgenic product class
missense_variant
(Wang et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Wang et al., 2007)
Mutagen
in vitro construct
(Wang et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-hParkin.G328E}
Cytology
Description

UASt regulates expression of a Hsap\PRKN cDNA containing a G328E mutation.

(Wang et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\PRKN
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      DOES NOT model  Parkinson's disease
      CEA
      (Wang et al., 2007)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      The G328E mutation frequently occurs in inherited Parkinson's disease, but no phenotype is observed when this mutation is introduced into flies.

      (Wang et al., 2007)
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Wang et al., 2007)
      PRKN:p.Gly328Glu
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      PRKN:p.Gly179Glu
      PRKN:p.Gly300Glu
      Associated human disease model(s)
      External database links
      UniProtKB/Swiss-Prot variant: PRKN_VAR_019756
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4elav.PU-mediated expression of Hsap\PARK2G328E.Scer\UAS does not compromise the overall anatomical integrity of the adult brain.

      PPL1 and PAM (as well as PAL, PPL2, PPM1/2 and PPM3) neurons remain intact in flies expressing Hsap\PARK2G328E.Scer\UAS via Scer\GAL4Ddc.PL.

      Scer\GAL4Ddc.PL, Hsap\PARK2G328E.Scer\UAS flies do not show a significant impairment in the ability in their climbing ability compared to controls.

      The indirect flight muscles of Scer\GAL4how-24B, Hsap\PARK2G328E.Scer\UAS flies do not show abnormal mitochondria - mitochondria are generally intact.

      (Wang et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\PARK2G328E.Scer\UAS
      Hsap\PRKNG328E.Scer\UAS
      Hsap\PRKNG328E.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)