FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Hsap\APLP2::HsapAPPα-6.LV.UAS
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General Information
Symbol
Hsap\APLP2::Hsap\APPα-6.LV.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0288003
Feature type
allele
Associated gene
Hsap\APLP2::Hsap\APP
Associated Insertion(s)
Carried in Construct
P{UAS-APP-APLP2.α-6.LV}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Stempfle et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-APP-APLP2.α-6.LV}
Cytology
Description

UAS regulatory sequences drive expression of a membrane-anchored protein designed to study γsecretase specificity. This reporter is a chimeric protein containing both Hsap\APLP2 and Hsap\APP coding sequence, with a signal sequence at the N-terminal end. Sequence encoding a lexA::VP16 driver is fused to the C-terminus of the protein. The driver sequence can potentially be released if the protein is cleaved by γsecretase.

(Stempfle et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\APLP2::Hsap\APP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The structure of the αAPP-APLP2 chimeric proteins is depicted in FIG. 5A of FBrf0211009.

      (Stempfle et al., 2010)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\APLP2::Hsap\APPα-6.LV.UAS
      Hsap\APLP2::Hsap\APPα-6.Scer\UAS.T:Hsap\MYC,T:Ecol\lexA,T:Hsim\VP16
      Name Synonyms
      Secondary FlyBase IDs
        References (1)