FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rlRNAi.UAS.cUa
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General Information
Symbol
Dmel\rlRNAi.UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0290182
Feature type
allele
Associated gene
Dmel\rl
Associated Insertion(s)
Carried in Construct
P{UAS-rl.RNAi.U}
Also Known As
UAS-rolled-RNAi
Key Links
Transgenic product class
RNAi_reagent
(FlyBase Curators, 2025-)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(FlyBase Curators, 2025-)
Mutagen
in vitro construct
(FlyBase Curators, 2025-)
Progenitor genotype
Carried in construct
P{UAS-rl.RNAi.U}
Cytology
Description

UAS regulatory sequences drive expression of an RNAi construct targeting rl.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
rl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  chromosome 16p11.2 deletion syndrome, 593-kb
      CEA
      (Park et al., 2017)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cardiomyopathy
      modeled by Hsap\RAF1gof.UAS
      (Yu et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4tin.CΔ4>rldsRNA.Scer\UAS.cUa flies have cardiac parameters that are similar to controls but the heart walls are thinner and have normal-appearing cardiomyocyte myofibrillar structure.

      (Yu et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhanced by
      NOT suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Cardiac-specific co-expression of Hsap\RAF1gof.Scer\UAS does not change the cardiac dimensions, hear wall thickness and cardiomyocyte myofibrillar architecture in Scer\GAL4tin.CΔ4>rldsRNA.Scer\UAS.cUa expressing flies.

      (Yu et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      rlRNAi.UAS.cUa
      rldsRNA.Scer\UAS.cUa
      rldsRNA.UAS.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (5)