FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Agam\GstE2UAS.ZANU
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General Information
Symbol
Agam\GstE2UAS.ZANU
Species
A. gambiae
Name
FlyBase ID
FBal0290344
Feature type
allele
Associated gene
Agam\GstE2
Associated Insertion(s)
Carried in Construct
M{UAS-AgGstE2.ZANU}
PBac{UAS-AgGstE2.ZANU}
Transgenic product class
polymorphic_sequence_variant
(Mitchell et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
polymorphic_sequence_variant
(Mitchell et al., 2014)
Mutagen
in vitro construct
(Mitchell et al., 2014, Daborn et al., 2012)
Progenitor genotype
Carried in construct
M{UAS-AgGstE2.ZANU}
PBac{UAS-AgGstE2.ZANU}
Cytology
Description

UASt regulatory sequences drive expression of Agam\GstE2 isolated from the DDT resistant ZAN/U A. gambiae strain; this coding sequence has a Thr residue at codon 114 and a Phe residue at codon 120.

(Mitchell et al., 2014)

UASt regulatory sequences drive expression of Agam\GstE2 isolated from the DDT resistant ZAN/U A. gambiae strain (this contains a single non-synonymous change relative to GenBank:AF316636).

(Daborn et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Agam\GstE2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Agam\GstE2Scer\UAS.cDa under the control of Scer\GAL4Cyp6g1.HR show a 10-11 fold increase in resistance to DDT compared to controls, while no increase in resistance to permethrin is seen.

      (Daborn et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Agam\GstE2Scer\UAS.cDa
      Agam\GstE2UAS.ZANU
      Agam\GstE2UAS.cDa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Daborn
      Secondary FlyBase IDs
        References (2)