FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PIG-VQ306A.ninaE
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General Information
Symbol
Dmel\PIG-VQ306A.ninaE
Species
D. melanogaster
Name
FlyBase ID
FBal0290879
Feature type
allele
Associated gene
Dmel\PIG-V
Associated Insertion(s)
Carried in Construct
P{ninaE-PIG-V.Q306A}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Rosenbaum et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Rosenbaum et al., 2012)
Mutagen
in vitro construct
(Rosenbaum et al., 2012)
Progenitor genotype
Carried in construct
P{ninaE-PIG-V.Q306A}
Cytology
Description

ninaE promoter sequences drive expression of PIG-V cDNA sequences containing the amino acid replacement Q306A.

(Rosenbaum et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
ninaE
Encoded product / tool
PIG-V
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:16,956,716..16,956,717 [+]
Reported amino acid change:

Q306A

Comment:

Mutation carried in a transgene. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Rosenbaum et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      PIG-VQ306A.ninaE partially rescues PIG-VA276V

      (Rosenbaum et al., 2012)
      Comments

      PIG-VA276V adults expressing PIG-VQ306A.ninaE show some retinal degeneration at 2 weeks of age: the rhabdomeres show signs of microvillar instability and there is an overall disruption in photoreceptor cell organisation compared to wild type.

      (Rosenbaum et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      PIG-VQ306A.ninaE
      Name Synonyms
      Secondary FlyBase IDs
        References (1)