FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\MANF::HsapCDNFUAS.cLa
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General Information
Symbol
Hsap\MANF::Hsap\CDNFUAS.cLa
Species
H. sapiens
Name
UAS construct a of Lindstrom
FlyBase ID
FBal0291176
Feature type
allele
Associated gene
Hsap\MANF::Hsap\CDNF
Associated Insertion(s)
Carried in Construct
P{UAS-N.HsMANF::C.HsCDNF}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Lindström et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-N.HsMANF::C.HsCDNF}
Cytology
Description

UAS regulates expression of a fusion gene in which the C-terminal domain of Hsap\MANF (residues 105-158) is replaced with that of Hsap\CDNF (residues 101-164). Honeybee melittin is used as the signal peptide.

(Lindström et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\MANF::Hsap\CDNF
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Scer\GAL4da.G32-mediated, but not Scer\GAL469B-mediated, expression of Hsap\MANF::Hsap\CDNFScer\UAS rescues ManfΔ96 mutant lethality to adulthood.

      (Lindström et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Hsap\MANF::Hsap\CDNFScer\UAS
      Hsap\MANF::Hsap\CDNFUAS.cLa
      Hsap\MANF::Hsap\CDNFUAS
      Name Synonyms
      UAS construct a of Lindstrom
      Secondary FlyBase IDs
        References (2)