FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Zmynd10EY10866
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General Information
Symbol
Dmel\Zmynd10EY10866
Species
D. melanogaster
Name
FlyBase ID
FBal0291679
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description
Allele components
Component
Use(s)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Zmynd10EY10866 mutants are viable and have no visible morphological defects. A climbing assay reveals that they are uncoordinated. This phenotype is not observed in revertant flies in which the P-element has been excised from the Zmynd10 locus.

No gross morphological defects are found in Ch neurons or terminal cilia in Zmynd10EY10866 mutants. Compartmentalization of the Ch neuron cilium also appears normal.

Homozygous Zmynd10EY10866 mutant males are infertile. In mutant males, the testes appear normal and contain developing sperm bundles. TEM shows that these sperm bundles generally consist of 64 sperm, suggesting that spermatocyte division and sperm differentiation are largely unaffected. However, motile sperm are not found as seminal vesicles are completely devoid of sperm, suggesting that the sperm are not transferred from the testes to the seminal vesicles.

Zmynd10EY10866 mutant sperm flagella exhibit a partial loss of dynein arms, with 12% showing axoneme splitting, whereby one or more doublet complexes become detached from the rest of the axoneme. in addition, ectopic luminal filaments (electron-dense cores) are also present within the 'A' microtubule of some doublets.

Compound action potentials can be evoked by sound in the antennal nerve of mutant flies, but the sound particle velocities required to elicit the response is increased compared to wild type. The displacement response of the antenna over a range of sound particle velocities is linearised, indicating loss of mechanical amplification.

External Data
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Phenotypic Class
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Additional Comments
Genetic Interactions
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Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

Coordinated locomotion, fertility and sperm motility are completely restored in Zmynd10EY10866 mutants in a Zmynd10T:Avic\GFP-YFP.Venus background.

Fertility is partially restored in Zmynd10EY10866 mutants in a Zmynd10T:Avic\GFP-YFP.Venus background.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG11253EY10866
Zmynd10EY10866
Name Synonyms
Secondary FlyBase IDs
  • FBal0290981
  • FBal0162598
References (4)