FlyBase Allele Report: Dmel\rswl[HMC02423]

General Information

Symbol

Dmel\rswl^HMC02423

Species

D. melanogaster

Name

FlyBase ID

FBal0292144

Feature type

allele

Associated gene

Dmel\rswl

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC02423}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC02423}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC02423

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^Act5C.PI

(Sen et al., 2016)

lethal - all die before end of larval stage, with Scer\GAL4^αTub84B.PL

(Sen et al., 2016)

lethal - all die before end of P-stage, with Scer\GAL4^Act5C.PI

(Sen et al., 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of rswl^HMC02423 under the control of either Scer\GAL4^αTub84B.PL or Scer\GAL4^Act5C.PI leads to lethality as no flies manage to eclose and in case of Scer\GAL4^αTub84B.PL-driven expression the larvae even fail to pupariate. Flies expressing rswl^HMC02423 RNAi under the Scer\GAL4^Act5C.PI driver display modest but reproducible delay in pupariation.

Expression of rswl^HMC02423 under the control of Scer\GAL4^ple.PF does not impair adult climbing abilities.

Expression of rswl^HMC02423 under the control of Scer\GAL4^αTub84B.PL does not cause any obvious mitochondrial morphology defects in larval brain neuroblasts.

(Sen et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions