10 day old flies expressing htt^HMS02845 under the control of Scer\GAL4^da.G32, raised under either dietary restriction (0.5% yeast) or an ad libitum diet (5% yeast), have increased survival to acute starvation; flies expressing htt^HMS02845 under the control of Scer\GAL4^da.G32, raised under either dietary restriction (0.5% yeast) or an ad libitum diet (5% yeast), have increased body mass but similar triglyceride levels as compared to controls.

Flies expressing htt^HMS02845 under the control of Scer\GAL4^{Act5C.Switch.PR} and treated with RU486 from day 1 of adulthood, have decreased lifespan when grown under dietary restriction (0.5% yeast), or increased lifespan when grown under an ad libitum diet (5% yeast), as compared to controls.